組織蛋白去乙酰酶抑制劑(英語(yǔ)：HDAC inhibitor，簡(jiǎn)寫(xiě)HDI或HDAC抑制劑)是一種透過(guò)抑制身體內(nèi)組織蛋白去乙酰酶功能的藥物類(lèi)別，亦存在于胎兒及花椒內(nèi)?，F(xiàn)時(shí)有健康食品生產(chǎn)商建議透過(guò)進(jìn)食花椒油而達(dá)至防癌的功效。
現(xiàn)時(shí)醫(yī)學(xué)界有研究透過(guò)“組織蛋白去乙酰酶抑制劑”來(lái)治療癌癥[1]及神經(jīng)退行性疾病(neurodegenerative diseases)。這些抑制劑的具體機(jī)制，例如有關(guān)的化合物如何達(dá)到有關(guān)的功效，到現(xiàn)在還未清楚。不過(guò)，有關(guān)文獻(xiàn)亦有提出可能的表觀遺傳學(xué)途徑[2] Richon et al.[3]發(fā)現(xiàn)HDAC抑制劑可以透過(guò)引導(dǎo)p21 (WAF1)來(lái)調(diào)節(jié)p53的腫瘤抑制功能[4]。
參考
- ↑ Marks PA, Dokmanovic M. Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert opinion on investigational drugs. 2005, 14 (12): 1497-511. doi:10.1517/13543784.14.12.1497. PMID 16307490.
- ↑ Claude Monneret. Histone deacetylase inhibitors for epigenetic therapy of cancer. Anticancer Drugs. April 2007, 18: 363-70.
- ↑ Richon VM, Sandhoff TW, Rifkind RA, Marks PA. AUG 29 2000. "Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation." Proceedings of the National Academy of Sciences of the United States of America 97(18):10014-10019.
- ↑ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. NOV 19 1993. "WAF1, a potential mediator of p53 tumor suppression." Cell (journal)|Cell 75(4):817-25.
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